CDK6 wt Allele

Preferred Label : CDK6 wt Allele;

NCIt synonyms : MGC59692; Cyclin-Dependent Kinase 6 Gene; PLSTIRE; Cyclin Dependent Kinase 6 wt Allele; MCPH12;

NCIt definition : Human CDK6 wild-type allele is located within 7q21-q22 and is approximately 232 kb in length. This allele, which encodes cyclin-dependent kinase 6 protein, is involved in cell cycle progression. Variation in the gene may influence stature. A translocation of this gene and the MLLT10 gene may be associated with acute lymphoblastic leukemia.;

NCIt note : Expression is analyzed as part of the 17-gene leukemia stem cell scoring system (LSC17). (Nature. 2016; doi:10.1038/nature20598.);

GenBank Accession Number : NM_001145306;

Details

Origin ID

C97385;

UMLS CUI

C3273388;

OMIM relation
- Cyclin-dependent kinase 6 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 7q21-q22 [NCIt concept]
gene_is_element_in_pathway
- Cell Cycle Pathway [NCIt concept]
- Chronic Myeloid Leukemia Pathway [NCIt concept]
- Coregulation Pathway for Androgen Receptor Activity [NCIt concept]
- Cyclin Regulation of Cell Cycle Pathway [NCIt concept]
- G1 to S Transition Pathway [NCIt concept]
- G1/S Checkpoint Pathway [NCIt concept]
- Glioblastoma Multiforme Pathway [NCIt concept]
- IL2/STAT5 Signaling Pathway [NCIt concept]
- Melanoma Pathway [NCIt concept]
- Non-Small Cell Lung Cancer Pathway [NCIt concept]
- Pancreatic Cancer Pathway [NCIt concept]
- Small Cell Lung Cancer Pathway [NCIt concept]
- p53 Signaling Pathway KEGG [NCIt concept]
gene_plays_role_in_process
- Cell Cycle Process [NCIt concept]
- Cell Cycle Progression [NCIt concept]
- Cell Cycle Regulation Process [NCIt concept]
- G1 Phase Process [NCIt concept]
- Negative Regulation of Cell Cycle [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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