Modified Vaccinia Virus Ankara Vaccine Expressing p53

Preferred Label : Modified Vaccinia Virus Ankara Vaccine Expressing p53;

NCIt synonyms : MVA-p53 Vaccine; p53-MVA Vaccine; MVA-p53; p53MVA; MVAp53 Vaccine;

NCIt definition : A cancer vaccine comprised of a recombinant modified vaccinia Ankara (MVA) viral vector encoding the wild-type form of the tumor protein p53 (wt p53), with potential immunostimulating and antineoplastic activities. Upon subcutaneous vaccination with MVA vaccine expressing p53, the expressed p53 may stimulate the host immune system to mount a p53-specific cytotoxic T-lymphocyte (CTL) response against tumor cells expressing p53, resulting in tumor cell lysis. The MVA viral vector, derived from the replication-competent strain Ankara, is a highly attentuated, replication-defective vaccinia strain and is incapable of virion assembly. The p53 gene, a tumor suppressor gene, is mutated in many cancer cell types.;

Details

Origin ID

C116868;

UMLS CUI

C1958831;

Automatic exact mappings (from CISMeF team)
- MVAp53 vaccine [MeSH concept]
- MVAp53 vaccine [MeSH Supplementary Concept]
Semantic type(s)
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- MVAp53 vaccine [MeSH Supplementary Concept]
- MVAp53 vaccine [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Cellular Tumor Antigen p53 [NCIt concept]

Keyword's position in hierarchy(ies) :

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