Histone Deacetylase 1

Preferred Label : Histone Deacetylase 1;

NCIt synonyms : HDAC1; HD1; EC 3.5.1.98; Histone Deacetylase-1;

NCIt definition : Histone deacetylase 1 (482 aa, 55 kDa) is encoded by the human HDAC1 gene. This protein is involved in chromatin remodeling and the negative regulation of apoptosis.;

NCIt note : Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. This protein belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. (LocusLink);

Details

Origin ID

C19671;

UMLS CUI

C1334032;

Currated CISMeF NLP mapping
- histone deacetylase 1 [MeSH Descriptor]
- histone deacetylase 1 [MeSH concept]
OMIM relation
- Histone deacetylase 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- HDAC1 protein, human [MeSH concept]
- HDAC1 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- HDAC1 Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
gene_product_has_biochemical_function
- Chromatin Remodeling Factor [NCIt concept]
gene_product_has_gene_product_variant
- HDAC1 NP_004955.2:p.Y303H [NCIt concept]
- HDAC1 Protein Variant [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Cell Cycle Pathway [NCIt concept]
- Chronic Myeloid Leukemia Pathway [NCIt concept]
- Estrogen Receptor Regulation by CARM1 Pathway [NCIt concept]
- G1/S Checkpoint Pathway [NCIt concept]
- Gene Expression Regulation by Vitamin D Receptor Pathway [NCIt concept]
- Gene Silencing Pathway [NCIt concept]
- Huntington's Disease Pathway [NCIt concept]
- Inhibition of Huntington's Disease Pathway [NCIt concept]
- MTA3 Pathway [NCIt concept]
- Notch Signaling Pathway [NCIt concept]
- Pitx2 Transcription Regulation Pathway [NCIt concept]
- Sumoylation Regulation of Transcriptional Repression Pathway [NCIt concept]
- T-Cell Apoptosis Pathway [NCIt concept]
- Tert Regulation Pathway [NCIt concept]
- WNT Signaling Pathway BioCarta [NCIt concept]
gene_product_plays_role_in_biological_process
- Chromatin Remodeling [NCIt concept]
- Deacetylation [NCIt concept]
- Histone Deacetylation [NCIt concept]
- Hydrolysis [NCIt concept]
- Transcriptional Regulation [NCIt concept]
is_target
- CoREST Inhibitor TNG260 [NCIt concept]
- Tucidinostat [NCIt concept]

Keyword's position in hierarchy(ies) :

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