" /> Sumoylation Regulation of Transcriptional Repression Pathway - CISMeF





Preferred Label : Sumoylation Regulation of Transcriptional Repression Pathway;

NCIt related terms : Sumoylation by RanBP2 Regulates Transcriptional Repression;

Alternative definition : BIOCARTA: Current data indicates that nuclear pore complex (NPC) RanBP2 (SUMO E3 ligase) protein sumoylates Mdm2 and HDAC proteins during nuclear translocation. A sumoylation-deficient HDAC showed reduced deacetylation activity and suggests that sumoylation may be an important regulatory mechanism for the control of transcriptional repression. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_ranbp2Pathway;

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30/07/2025


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