Sumoylation Regulation of Transcriptional Repression Pathway

Preferred Label : Sumoylation Regulation of Transcriptional Repression Pathway;

NCIt related terms : Sumoylation by RanBP2 Regulates Transcriptional Repression;

Alternative definition : BIOCARTA: Current data indicates that nuclear pore complex (NPC) RanBP2 (SUMO E3 ligase) protein sumoylates Mdm2 and HDAC proteins during nuclear translocation. A sumoylation-deficient HDAC showed reduced deacetylation activity and suggests that sumoylation may be an important regulatory mechanism for the control of transcriptional repression. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_ranbp2Pathway;

Details

Origin ID

C39211;

UMLS CUI

C1515053;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- E3 SUMO-Protein Ligase PIAS1 [NCIt concept]
- E3 SUMO-Protein Ligase RanBP2 [NCIt concept]
- E3 Ubiquitin-Protein Ligase MDM2 [NCIt concept]
- GTP-Binding Nuclear Protein Ran [NCIt concept]
- Histone Deacetylase 1 [NCIt concept]
- Histone Deacetylase 4 [NCIt concept]
- Histone Deacetylase 6 [NCIt concept]
- Histone Deacetylase 9 [NCIt concept]
- Ran GTPase-Activating Protein 1 [NCIt concept]
- Small Ubiquitin-Related Modifier 1 [NCIt concept]
pathway_has_gene_element
- HDAC1 wt Allele [NCIt concept]
- HDAC4 wt Allele [NCIt concept]
- HDAC6 wt Allele [NCIt concept]
- HDAC9 wt Allele [NCIt concept]
- MDM2 wt Allele [NCIt concept]
- PIAS1 wt Allele [NCIt concept]
- RAN wt Allele [NCIt concept]
- RANBP2 wt Allele [NCIt concept]
- RANGAP1 wt Allele [NCIt concept]
- SUMO1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients