Histone Deacetylase 4

Preferred Label : Histone Deacetylase 4;

NCIt synonyms : HDAC-A; Histone Deacetylase A; HDAC4; HD4; EC 3.5.1.98; Histone Deacetylase-4;

NCIt definition : Histone deacetylase 4 (1084 aa, 119 kDa) is encoded by the human HDAC4 gene. This protein plays a role in the regulation of cell differentiation and histone deacetylation.;

NCIt note : This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. (LocusLink);

Details

Origin ID

C19673;

UMLS CUI

C0910119;

OMIM relation
- Histone deacetylase 4 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- HDAC4 Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
gene_product_has_biochemical_function
- Chromatin Remodeling Factor [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Estrogen Receptor Regulation by CARM1 Pathway [NCIt concept]
- Sumoylation Regulation of Transcriptional Repression Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Chromatin Remodeling [NCIt concept]
- Deacetylation [NCIt concept]
- Histone Deacetylation [NCIt concept]
- Hydrolysis [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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