Histone Deacetylase 6

Preferred Label : Histone Deacetylase 6;

NCIt synonyms : HDAC6; EC 3.5.1.98; HD6; Histone Deacetylase-6;

NCIt definition : Histone deacetylase 6 (1215 aa, 131 kDa) is encoded by the human HDAC6 gene. This protein plays a role in the unfolded protein response, cell motility and the deacetylation of both histones and tubulin.;

Details

Origin ID

C19679;

UMLS CUI

C1448099;

OMIM relation
- Histone deacetylase 6 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- HDAC6 protein, human [MeSH concept]
- HDAC6 protein, human [MeSH Supplementary Concept]
- Histone Deacetylase 6 [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- HDAC6 Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
gene_product_has_biochemical_function
- Chromatin Remodeling Factor [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Estrogen Receptor Regulation by CARM1 Pathway [NCIt concept]
- Sumoylation Regulation of Transcriptional Repression Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Progression [NCIt concept]
- Chromatin Remodeling [NCIt concept]
- Deacetylation [NCIt concept]
- Developmental Process [NCIt concept]
- Histone Deacetylation [NCIt concept]
- Hydrolysis [NCIt concept]
- Transcriptional Regulation [NCIt concept]
is_target
- HDAC6 Inhibitor KA2507 [NCIt concept]
- LSD1/HDAC6 Inhibitor JBI-802 [NCIt concept]
- Ricolinostat [NCIt concept]

Keyword's position in hierarchy(ies) :

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