Preferred Label : HDAC6 Inhibitor KA2507;
NCIt synonyms : HDAC6i KA2507;
NCIt related terms : KA-2507;
NCIt definition : An orally bioavailable inhibitor of histone deacetylase (HDAC) type 6 (HDAC6; HDAC-6),
with potential antineoplastic activity. Upon administration, KA2507 targets, binds
to and inhibits the activity of HDAC6. This results in an accumulation of highly acetylated
chromatin histones, the induction of chromatin remodeling and an altered pattern of
gene expression. Specifically, inhibition of HDAC6 prevents STAT3 activity, which
leads to a reduction in programmed death-1 (PD-1) expression. Eventually, this results
in a selective transcription of tumor suppressor genes, tumor suppressor protein-mediated
inhibition of tumor cell division and an induction of apoptosis in tumor cells that
overexpress HDAC6. HDAC6, which is upregulated in many tumor cell types, deacetylates
chromatin histone proteins.;
UNII : VQ7NU11KRM;
Molecule name : KA2507;
NCI Metathesaurus CUI : CL522984;
Origin ID : C135629;
UMLS CUI : C4525952;
Semantic type(s)
- concept_is_in_subset
- has_target
