Histone Deacetylase 6

Preferred Label : Histone Deacetylase 6;

MeSH definition : A class II histone deacetylase that removes acetyl groups from N-terminal LYSINES of HISTONE H2A; HISTONE H2B; HISTONE H3; and HISTONE H4. It plays a critical role in EPIGENETIC REPRESSION and regulation of GENETIC TRANSCRIPTION, as well as CELL MOTILITY through deacetylation of TUBULIN. It also targets misfolded proteins for clearance by AUTOPHAGY when MOLECULAR CHAPERONE-mediated folding is overwhelmed.;

Registry Number MeSH : EC 3.5.1.98;

UNII : EC 3.5.1.98;

Details

Origin ID

D000073864;

UMLS CUI

C0969119;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Histone Deacetylase 6 [NCIt concept]
- Histone deacetylase 6 [OMIM gene]
- histone deacetylase 6 [ORDO Gene]
- histone deacetylase 6 [HGNC gene]
Record concept(s)
- Histone Deacetylase 6 [MeSH concept]
Related MeSH Supplementary Concept(s)
- HDAC6 protein, drosophila [MeSH Supplementary Concept]
- HDAC6 protein, human [MeSH Supplementary Concept]
- HDAC6 protein, rat [MeSH Supplementary Concept]
- HDAC6 protein, zebrafish [MeSH Supplementary Concept]
- Hdac6 protein, mouse [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Histone Deacetylase 6 [NCIt concept]

Keyword's position in hierarchy(ies) :

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