" /> Ricolinostat - CISMeF





Preferred Label : Ricolinostat;

NCIt synonyms : Histone Deacetylase 6 Inhibitor ACY-1215; 2-(Diphenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide; Rocilinostat;

NCIt definition : An orally bioavailable, specific inhibitor of histone deacetylase 6 (HDAC6) with potential antineoplastic activity. Ricolinostat selectively targets and binds to HDAC6, thereby disrupting the Hsp90 protein chaperone system through hyperacetylation of Hsp90 and preventing the subsequent aggresomal protein degradation. This leads to an accumulation of unfolded and misfolded ubiquitinated proteins and may eventually induce cancer cell apoptosis, and inhibition of cancer cell growth. HDAC6, a class II HDAC deacetylase located in the cytoplasm, appears to play a key role in the formation and activation of the aggresomes needed for degradation of misfolded proteins. Compared to non-selective HDAC inhibitor, ACY-1215 is able to reduce the toxic effects on normal, healthy cells.;

UNII : WKT909C62B;

InChIKey : QGZYDVAGYRLSKP-UHFFFAOYSA-N;

CAS number : 1316214-52-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1316214-52-4 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : ACY-1215;

Codes from synonyms : 442;

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Keyword's position in hierarchy(ies) : arborescence

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12/05/2024


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