T-Cell Apoptosis Pathway

Preferred Label : T-Cell Apoptosis Pathway;

NCIt related terms : Role of MEF2D in T-cell Apoptosis;

Alternative definition : BIOCARTA: Mef2 (Myocyte enhancer factor 2) transcription factors play a role in T-Cell calcium induced apoptosis. Several factors regulate Mef2 transcription factors, including Map kinases and histone deacetylase (HDAC) enzymes. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_mef2dPathway;

Details

Origin ID

C39149;

UMLS CUI

C1515125;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Gamma-1 [NCIt concept]
- Calcineurin-Binding Protein Cabin-1 [NCIt concept]
- HLA Class II Histocompatibility Antigen, DR Alpha Chain [NCIt concept]
- Histone Acetyltransferase p300 [NCIt concept]
- Histone Deacetylase 1 [NCIt concept]
- Histone Deacetylase 2 [NCIt concept]
- Myocyte-Specific Enhancer Factor 2D [NCIt concept]
- Nuclear Receptor Subfamily 4 Group A Member 1 [NCIt concept]
- Protein Kinase C Alpha Type [NCIt concept]
- Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Alpha Isoform [NCIt concept]
- Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Beta Isoform [NCIt concept]
- Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Gamma Isoform [NCIt concept]
- T-Cell Surface Glycoprotein CD3 Gamma Chain [NCIt concept]
- Tyrosine-Protein Kinase Fyn [NCIt concept]
- Tyrosine-Protein Kinase Lck [NCIt concept]
- Tyrosine-Protein Kinase ZAP-70 [NCIt concept]
pathway_has_gene_element
- CABIN1 wt Allele [NCIt concept]
- CD3G wt Allele [NCIt concept]
- EP300 wt Allele [NCIt concept]
- FYN wt Allele [NCIt concept]
- HDAC1 wt Allele [NCIt concept]
- HDAC2 wt Allele [NCIt concept]
- HLA-DRA wt Allele [NCIt concept]
- LCK wt Allele [NCIt concept]
- MEF2D wt Allele [NCIt concept]
- NR4A1 wt Allele [NCIt concept]
- PLCG1 wt Allele [NCIt concept]
- PPP3CA wt Allele [NCIt concept]
- PPP3CB wt Allele [NCIt concept]
- PPP3CC wt Allele [NCIt concept]
- PRKCA wt Allele [NCIt concept]
- ZAP70 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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