ZAP70 wt Allele

Preferred Label : ZAP70 wt Allele;

NCIt synonyms : STD; SRK; ZAP-70 Gene; ZAP-70; Zeta-Chain (TCR) Associated Protein Kinase 70kDa wt Allele; ZAP70; ZAP-70 wt Allele;

NCIt definition : Human ZAP70 wild-type allele is located within 2q12 and is approximately 26 kb in length. This allele, which encodes ZAP70 protein, plays a role in the mediation of signal transduction involving cellular effectors in lymphocyte activation. ZAP70 ab gene aberrations cause Selective T-Cell Defect disease.;

GenBank Accession Number : NM_001079;

Details

Origin ID

C52231;

UMLS CUI

C1705831;

OMIM relation
- Zeta-chain-associated protein kinase [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_associated_with_disease
- Severe Combined Immunodeficiency [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_has_abnormality
- ZAP70 Messenger RNA Overexpression [NCIt concept]
gene_in_chromosomal_location
- 2q12 [NCIt concept]
gene_involved_in_pathogenesis_of_disease
- Chronic Lymphocytic Leukemia with Unmutated Immunoglobulin Heavy Chain Variable-Region Gene [NCIt concept]
- Small Lymphocytic Lymphoma with Unmutated Immunoglobulin Heavy Chain Variable-Region Gene [NCIt concept]
gene_is_element_in_pathway
- CSK Protein Kinase Activation Pathway [NCIt concept]
- Natural Killer Cell-Mediated Cytotoxicity Pathway [NCIt concept]
- Primary Immunodeficiency Pathway [NCIt concept]
- T Cell Receptor Signaling Pathway BioCarta [NCIt concept]
- T Cell Receptor Signaling Pathway KEGG [NCIt concept]
- T-Cell Apoptosis Pathway [NCIt concept]
- T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells [NCIt concept]
- T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells [NCIt concept]
- TCR Activation Pathway [NCIt concept]
gene_plays_role_in_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Signal Transduction [NCIt concept]
- T-Cell Activation [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]

Keyword's position in hierarchy(ies) :

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