HDAC2 wt Allele

Preferred Label : HDAC2 wt Allele;

NCIt synonyms : Histone Deacetylase 2 wt Allele; YAF1; RPD3; HD2; KDAC2;

NCIt definition : Human HDAC2 wild-type allele is located within 6q21 and is approximately 30 kb in length. This allele, which encodes histone deacetylase 2 protein, is involved in both the deacetylation of lysine residues on the N-terminal region of the core histones (H2A, H2B, H3 and H4) and the formation of transcriptional repressor complexes. Reduced expression of the HDAC2 gene is associated with chronic obstructive pulmonary disease.;

GenBank Accession Number : NM_001527;

Détails

Origin ID

C49390;

UMLS CUI

C1706172;

OMIM relation
- Histone deacetylase 2 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_has_physical_location
- 6: 114398967-114368621 [NCIt concept]
gene_in_chromosomal_location
- 6q21 [NCIt concept]
gene_is_element_in_pathway
- Cell Cycle Pathway [NCIt concept]
- Chronic Myeloid Leukemia Pathway [NCIt concept]
- Estrogen Receptor Regulation by CARM1 Pathway [NCIt concept]
- Gene Silencing Pathway [NCIt concept]
- Huntington's Disease Pathway [NCIt concept]
- Macrophage Differentiation Pathway [NCIt concept]
- Notch Signaling Pathway [NCIt concept]
- T-Cell Apoptosis Pathway [NCIt concept]
gene_plays_role_in_process
- Chromatin Remodeling [NCIt concept]
- Hydrolysis [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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