MTA3 Pathway - CISMeF

Preferred Label : MTA3 Pathway;

NCIt related terms : Downregulated of MTA-3 in ER-negative Breast Tumors;

Alternative definition : BIOCARTA: Approximately 30% of breast carcinomas lack ER expression. Presumably, these breast cancers become estrogen independent through genetic alterations that bypass the requirement for ER-dependent stimulation of cell proliferation. As such, estrogen receptor is a key regulator of proliferation and differentiation in mammary epithelia and represents a crucial prognostic indicator and therapeutic target in breast cancer. Mechanistically, estrogen receptor induces changes in gene expression through direct gene activation of a number of genes (e.g., cathepsin D, HSP27, alpha-tubulin, glyceraldehyde-3-phosphatase, Pdzk1, Greb) and also through the biological functions of target loci. The product of human MTA3 has been identified as an estrogen-dependent component of the Mi-2/NuRD transcriptional corepressor in breast epithelial cells and demonstrates that MTA3 constitutes a key component of an estrogen-dependent pathway regulating growth and differentiation. The absence of estrogen receptor or of MTA3 leads to aberrant expression of the transcriptional repressor Snail, a master regulator of epithelial to mesenchymal transitions. Aberrant Snail expression results in loss of expression of the cell adhesion molecule E-cadherin, an event associated with changes in epithelial architecture and invasive growth. MTA3 is the mechanistic link between estrogen receptor status and invasive growth of breast cancers. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_mta3Pathway;

Details

Origin ID

C39158;

UMLS CUI

C1518143;

Semantic type(s)
- Genetic Function [UMLS semantic type]
has_gene_product_element
- Cadherin-1 [NCIt concept]
- Cathepsin D [NCIt concept]
- Estrogen Receptor [NCIt concept]
- Heat Shock Protein Beta-1 [NCIt concept]
- Histone Deacetylase 1 [NCIt concept]
- Methyl-CpG-Binding Domain Protein 3 [NCIt concept]
- Na(+)/H(+) Exchange Regulatory Cofactor NHE-RF3 [NCIt concept]
- Protein GREB1 [NCIt concept]
- Tubulin Alpha-3C/D Chain [NCIt concept]
pathway_has_gene_element
- CDH1 wt Allele [NCIt concept]
- CTSD wt Allele [NCIt concept]
- ESR1 wt Allele [NCIt concept]
- GREB1 wt Allele [NCIt concept]
- HDAC1 wt Allele [NCIt concept]
- HSPB1 wt Allele [NCIt concept]
- MBD3 wt Allele [NCIt concept]
- PDZK1 wt Allele [NCIt concept]
- TUBA3C wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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