Elacestrant - CISMeF

Preferred Label : Elacestrant;

NCIt synonyms : SERD/SERM RAD1901; (6R)-6-(2-(Ethyl((4-(2- (ethylamino)ethyl)phenyl)methyl)amino)-4-methoxyphenyl)- 5,6,7,8-tetrahydronaphthalen-2-ol;

NCIt definition : An orally available, selective estrogen receptor degrader (SERD), with antineoplastic activity. Upon oral administration, elacestrant acts as a SERD, which binds to the estrogen receptor (ER) and induces a conformational change that results in the proteosomal degradation of the receptor. This prevents ER-mediated signaling and inhibits proliferation of ER-expressing cancer cells.;

UNII : FM6A2627A8;

InChIKey : SIFNOOUKXBRGGB-AREMUKBSSA-N;

CAS number : 722533-56-4;

Molecule name : ER-306323; RAD-1901; RAD 1901;

Codes from synonyms : 18359;

Details

Origin ID

C120211;

UMLS CUI

C4682404;

Automatic exact mappings (from CISMeF team)
- (6R)-6-(2-(ethyl((4-(2-(ethylamino)ethyl)phenyl)methyl)amino)-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-ol [MeSH concept]
Currated CISMeF NLP mapping
- Elacestrant [SMS substance]
- elacestrant [MeSH Supplementary Concept]
- elacestrant [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- elacestrant [MeSH Supplementary Concept]
- elacestrant [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Estrogen Receptor [NCIt concept]

Keyword's position in hierarchy(ies) :

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