Preferred Label : SERD ZB-716;
NCIt synonyms : Borestrant; Selective Estrogen Receptor Degrader ZB716; Selective Estrogen Receptor Alpha Degrader ZB716;
NCIt related terms : ZB-716;
NCIt definition : An orally bioavailable selective estrogen receptor degrader/downregulator (SERD) and
a structural analog of fulvestrant, with potential antineoplastic activity. Upon oral
administration, SERD ZB-716 specifically targets and binds to the estrogen receptor
(ER) and induces a conformational change that promotes ER degradation. This prevents
ER-mediated signaling and inhibits both the growth and survival of ER-expressing cancer
cells.;
UNII : E35ZN95LMT;
CAS number : 1853279-29-4;
Molecule name : ZB-716; ZB 716;
NCI Metathesaurus CUI : CL1661906;
Origin ID : C179265;
UMLS CUI : C5555565;
Semantic type(s)
- concept_is_in_subset
- has_target
