Preferred Label : ER Alpha-targeting Chimeric Protein Degrader AC682;
NCIt synonyms : ER Degrader AC0682; ERa Degrader AC0682; ER-alpha Protein Degrader AC0682; Estrogen Receptor Alpha-targeting Chimeric Protein Degrader AC0682;
NCIt definition : An orally bioavailable, selective estrogen receptor (ER) alpha-targeted chimeric protein
degrader, with potential antineoplastic activity. Upon oral administration, ER alpha-targeting
chimeric protein degrader AC682 targets ER alpha wild-type and mutants and induces
the degradation of ER alpha proteins. This decreases ER alpha protein levels, decreases
the expression of ER alpha-target genes and halts ER-mediated signaling. This results
in an inhibition of proliferation in ER alpha-overexpressing tumor cells. ER alpha
is overexpressed in a variety of cancers and plays a key role in cancer cell proliferation.
AC682 is able to cross the blood-brain barrier (BBB).;
Molecule name : AC-0682; AC 0682; AC-682; AC 682;
NCI Metathesaurus CUI : CL1773473;
Origin ID : C185124;
UMLS CUI : C5666941;
Semantic type(s)
- concept_is_in_subset
- has_target
