Preferred Label : SERD ZN-c5;
NCIt synonyms : Selective Estrogen Receptor Downregulator ZN-c5; Selective Estrogen Receptor Degrader ZN-c5;
NCIt definition : An orally available selective estrogen receptor degrader/downregulator (SERD), with
potential antineoplastic activity. Upon oral administration, SERD ZN-c5 specifically
targets and binds to the estrogen receptor (ER) and induces a conformational change
that results in ER degradation. This prevents ER-mediated signaling and inhibits both
the growth and survival of ER-expressing cancer cells.;
Molecule name : ZN c5; ZN-c5;
NCI Metathesaurus CUI : CL972255;
Origin ID : C167267;
UMLS CUI : C5238412;
Semantic type(s)
- concept_is_in_subset
- has_target
