Preferred Label : Tamoxifen Citrate;
NCIt synonyms : (Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine 2-Hydroxy-1,2,3-propanetricarboxylate; 1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene Citrate; TAM; (Z)-2-[4-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine citrate; Tamoxifen;
NCIt related terms : Nolvadex;
NCIt definition : The citrate salt of an antineoplastic nonsteroidal selective estrogen receptor modulator
(SERM). Tamoxifen competitively inhibits the binding of estradiol to estrogen receptors,
thereby preventing the receptor from binding to the estrogen-response element on DNA.
The result is a reduction in DNA synthesis and cellular response to estrogen. In addition,
tamoxifen up-regulates the production of transforming growth factor B (TGFb), a factor
that inhibits tumor cell growth, and down-regulates insulin-like growth factor 1 (IGF-1),
a factor that stimulates breast cancer cell growth. Tamoxifen also down-regulates
protein kinase C (PKC) expression in a dose-dependant manner, inhibiting signal transduction
and producing an antiproliferative effect in tumors such as malignant glioma and other
cancers that overexpress PKC.;
Alternative definition : NCI-GLOSS: A drug used to treat certain types of breast cancer in women and men. It
is also used to prevent breast cancer in women who have had ductal carcinoma in situ
(abnormal cells in the ducts of the breast) and in women who are at a high risk of
developing breast cancer. Tamoxifen citrate is also being studied in the treatment
of other types of cancer. It blocks the effects of the hormone estrogen in the breast.
Tamoxifen citrate is a type of antiestrogen.;
UNII : 7FRV7310N6;
InChIKey : FQZYTYWMLGAPFJ-OQKDUQJOSA-N;
CAS number : 54965-24-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 54965-24-1
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Drug name : Nolvadex; Clonoxifen; Noltam; Noxitem; Tamizam; Oestrifen; PMS-Tamoxifen; Soltamox; Tamaxin; Oncotam; Nourytam; Zemide; Tamax; Dignotamoxi; Novofen; Tamoxifeni Citras; Fentamox; Nolgen; Kessar; Genox; Tamoxasta; Ledertam; Tamofen; Jenoxifen; Lesporene; Apo-Tamox; Tamifen; Ebefen; Estroxyn; Emblon; Novo-Tamoxifen; Gen-Tamoxifen; Nolvadex-D;
Molecule name : ICI-46474; ICI 46,474;
Chemical formula : C26H29NO.C6H8O7;
NSC code : 180973;
ChEBI ID : CHEBI:9397;
Codes from synonyms : NSC0180973; 00565; CDR0000509341;
Origin ID : C855;
UMLS CUI : C0079589;
False automatic mappings
- Semantic type(s)
- Validated automatic mappings to NTBT
- chemical_or_drug_is_metabolized_by_enzyme
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_component_of_chemotherapy_regimen
- is_salt_form_of
