Preferred Label : Taragarestrant;
NCIt synonyms : SERD D-0502; Selective Estrogen Receptor Downregulator D-0502; (2E)-3-(3,5-Dichloro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1hpyrido(3,4-b)indol-1-yl)phenyl)prop-2-enoic
acid; 2-Propenoic acid, 3-(3,5-dichloro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1H-pyrido(3,4-b)indol-1-yl)phenyl)-,
(2E)-;
NCIt definition : An orally available, nonsteroidal selective estrogen receptor degrader/downregulator
(SERD), with potential antineoplastic activity. Upon oral administration, taragarestrant
specifically targets and binds to the estrogen receptor (ER) and induces a conformational
change that promotes ER degradation. This prevents ER-mediated signaling and inhibits
both the growth and survival of ER-expressing cancer cells.;
UNII : KD4HIM135V;
CAS number : 2118899-51-5;
Molecule name : D-0502; D 0502;
NCI Metathesaurus CUI : CL935902;
Origin ID : C156735;
UMLS CUI : C5706571;
Semantic type(s)
- concept_is_in_subset
- has_target
