Preferred Label : Raloxifene Hydrochloride;
NCIt synonyms : Keoxifene Hydrochloride; Raloxifene HCl; (6-Hydroxy-2-(4-hydroxyphenyl)benzo(b)thien-3-yl)(4-(2-(1-piperidinyl)ethoxy)phenyl)methanone
Hydrochloride;
NCIt related terms : Evista; Raloxifene.HCl;
NCIt definition : The hydrochloride salt form of raloxifene, a selective benzothiophene estrogen receptor
modulator (SERM) with lipid lowering effects and activity against osteoporosis. Raloxifene
hydrochloride specifically binds to estrogen receptors in responsive tissue, including
liver, bone, breast, and endometrium. The resulting ligand-receptor complex is translocated
to the nucleus where, depending on the tissue type, it promotes or suppresses the
transcription of estrogen-regulated genes, thereby exerting its agonistic or antagonistic
effects. This agent functions as an estrogen agonist in lipid metabolism, thereby
decreasing total and LDL cholesterol levels. In tissue like bone, it decreases bone
resorption and bone turnover and increases bone mineral density. Raloxifene hydrochloride
acts as an estrogen antagonist in uterine and breast tissue. This agent also exerts
an anti-proliferative effect on estrogen-sensitive breast cancer.;
Alternative definition : NCI-GLOSS: A drug used to reduce the risk of invasive breast cancer in postmenopausal
women who are at high risk of the disease or who have osteoporosis. It is also used
to prevent and treat osteoporosis in postmenopausal women. It is also being studied
in the prevention of breast cancer in certain premenopausal women and in the prevention
and treatment of other conditions. Evista blocks the effects of the hormone estrogen
in the breast and increases the amount of calcium in bone. It is a type of selective
estrogen receptor modulator (SERM).;
UNII : 4F86W47BR6;
InChIKey : BKXVVCILCIUCLG-UHFFFAOYSA-N;
CAS number : 82640-04-8;
Drug name : Optruma; Evista;
Molecule name : LY-156758;
Chemical formula : C28H27NO4S.HCl;
NSC code : 706725;
ChEBI ID : CHEBI:50740;
Codes from synonyms : NSC0706725; CDR0000572250; 30622; CDR0000572252;
Origin ID : C1762;
UMLS CUI : C0618111;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_salt_form_of
