Preferred Label : Genistein;
NCIt synonyms : Genestein; Genisteol; Prunetol; 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; 4',5,7-Trihydroxyisoflavone;
NCIt related terms : 4',5, 7-Trihydroxyisoflavone;
NCIt definition : A soy-derived isoflavone and phytoestrogen with antineoplastic activity. Genistein
binds to and inhibits protein-tyrosine kinase, thereby disrupting signal transduction
and inducing cell differentiation. This agent also inhibits topoisomerase-II, leading
to DNA fragmentation and apoptosis, and induces G2/M cell cycle arrest. Genistein
exhibits antioxidant, antiangiogenic, and immunosuppressive activities. (NCI04);
Alternative definition : CRCH: An isoflavone with a hydroxyl group on the B-ring and a second hydroxyl group
on the A-ring.; NCI-GLOSS: An isoflavone found in soy products. Soy isoflavones are being studied
to see if they help prevent cancer.;
UNII : DH2M523P0H;
InChIKey : TZBJGXHYKVUXJN-UHFFFAOYSA-N;
CAS number : 446-72-0;
Unit used : mcg;
Chemical formula : C15H10O5;
NSC code : 36586;
ChEBI ID : CHEBI:28088;
Codes from synonyms : 04350; CDR0000046107; NSC0036586;
Origin ID : C1113;
UMLS CUI : C0061202;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
