Preferred Label : Pelp1 Estrogen Receptor Pathway;
NCIt related terms : Pelp1 Modulation of Estrogen Receptor Activity;
Alternative definition : BIOCARTA: Proline-, glutamic acid-, leucine-rich protein 1 (Pelp1 or modulator of
nongenomic activity of estrogen, MNAR) is a recently discovered transmitter of estrogen
signals. The receptors for estrogen (ER), progestin (PR), androgen (AR) and others
are steroid hormone receptors, which are part of a large family of ligand-inducible
transcription factors. It has been established that estrogen has at least two courses
of action termed classical or genomic and nongenomic. The classical activation cascade
is well known. The nongenomic or nontranscriptional activation cascade for the estrogen
receptor was determined based on the rapid response times observed for the activation
of the MAPK cascade and other cell proliferation effects. The mechanism was believed
to involve a membrane bound ER but attempts to isolate such a protein have not been
successful. A second possibility would involve a scaffold protein that interacts with
ER. Pelp1 appears to fit the second scenario. Pelp1 was first isolated as a coactivator
of transcription for ER-alpha. It was observed that Pelp1 was expressed at levels
3-5 times normal in breast tumors. Several breast cancer cell lines have been shown
to express Pelp1. Like many nuclear hormone receptors Pelp1 also interacts with Cbp
and p300. More recently it has been demonstrated that Pelp1 mediates the interaction
of ER and Src leading to the activation of the Mitogen Activated Protein Kinases Erk1
and Erk2. (This definition may be outdated - see the DesignNote.);
NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by
BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus
staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA
Definition might be outdated or inaccurate. Please see the Terms and Conditions for
Use at http://www.biocarta.com/.;
Biocarta ID : h_pelp1Pathway;
Origin ID : C39186;
UMLS CUI : C1518940;
Semantic type(s)
- has_gene_product_element
- pathway_has_gene_element
