Preferred Label : SERD SHR9549;
NCIt synonyms : Selective Estrogen Receptor Degrader SHR9549; Selective Estrogen Receptor Downregulator SHR9549;
NCIt definition : An orally available selective estrogen receptor degrader/downregulator (SERD), with
potential antineoplastic activity. Upon oral administration, SERD SHR9549 specifically
targets and binds to the estrogen receptor (ER) and induces a conformational change
that promotes ER degradation. This prevents ER-mediated signaling and inhibits both
the growth and survival of ER-expressing cancer cells.;
Molecule name : SHR 9549; SHR-9549;
NCI Metathesaurus CUI : CL978680;
Origin ID : C165550;
UMLS CUI : C5239490;
Semantic type(s)
- concept_is_in_subset
- has_target
