Preferred Label : Rintodestrant;
NCIt synonyms : Selective Estrogen Receptor Degrader G1T48; Selective Estrogen Receptor Downregulator G1T48;
NCIt definition : An orally available selective estrogen receptor degrader/downregulator (SERD), with
potential antineoplastic activity. Upon oral administration, rintodestrant specifically
targets and binds to the estrogen receptor alpha (ERalpha; ERa; ESR1) and induces
a conformational change that promotes ERalpha degradation and downregulation. This
prevents ERalpha-mediated signaling and inhibits both the growth and survival of ERalpha-expressing
cancer cells.;
UNII : W3Y784Y0ES;
InChIKey : KOAITBOFZOEDOC-BJMVGYQFSA-N;
CAS number : 2088518-51-6;
Molecule name : SERD G1T48; G1T48;
NCI Metathesaurus CUI : CL552249;
Origin ID : C175853;
UMLS CUI : C5446793;
Semantic type(s)
- concept_is_in_subset
- has_target
