Preferred Label : Estrogen Receptor Degrader AC699;
NCIt synonyms : ER-targeting Chimeric Protein Degrader AC699; ER Degrader AC699;
NCIt definition : An orally bioavailable estrogen receptor (ER)-targeted chimeric protein degrader composed
of ligands of ER and cereblon (CRBN) E3 ubiquitin ligase, with potential antineoplastic
activity. Upon oral administration of ER degrader AC699, the ER-targeting moiety targets
and binds to ER, and the CRBN-binding moiety recruits CRBN, a component of the CRL4-CRBN
E3 ubiquitin ligase complex. This catalyzes ubiquitination and proteasome-mediated
degradation of ER, prevents ER-mediated signaling, and inhibits both the growth and
survival of ER-expressing cancer cells. ER is overexpressed in a variety of cancers
and plays a key role in cancer cell proliferation.;
Molecule name : AC 699; AC-699;
NCI Metathesaurus CUI : CL1906235;
Origin ID : C199299;
concept_is_in_subset
- has_target
