Preferred Label : Amcenestrant;
NCIt synonyms : Selective Estrogen Receptor Degrader SAR439859; Selective Estrogen Receptor Downregulator SAR439859;
NCIt definition : An orally available, nonsteroidal selective estrogen receptor degrader/downregulator
(SERD), with potential antineoplastic activity. Upon oral administration, amcenestrant
specifically targets and binds to the estrogen receptor (ER) and induces a conformational
change that promotes ER degradation. This prevents ER-mediated signaling and inhibits
both the growth and survival of ER-expressing cancer cells.;
UNII : TBF1NHY02O;
InChIKey : KISZAGQTIXIVAR-VWLOTQADSA-N;
CAS number : 2114339-57-8;
Molecule name : SAR-439859; SAR 439859;
NCI Metathesaurus CUI : CL538418;
Origin ID : C174915;
UMLS CUI : C5421014;
Semantic type(s)
- concept_is_in_subset
- has_target
