" /> 2-Methoxyestradiol - CISMeF





Preferred Label : 2-Methoxyestradiol;

NCIt synonyms : 2-Methoxy Estradiol; (17beta)-2-Methoxyestra-1,3,5(10)-triene-3,17-diol; 2ME2; 2-MeE2; 2-Methoxyestradiol; 2-MeOE2;

NCIt definition : An orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing endothelial cell proliferation and inducing endothelial cell apoptosis. This agent also inhibits tumor cell growth by binding to tubulin, resulting in antimitotic activity, and by inducing caspase activation, resulting in cell cycle arrest in the G2 phase, DNA fragmentation, and apoptosis. (NCI04);

Alternative definition : NCI-GLOSS: 2ME2. A drug derived from estrogen that belongs to the family of drugs called angiogenesis inhibitors. It prevents the formation of new blood vessels that tumors need in order to grow.;

UNII : 6I2QW73SR5;

InChIKey : CQOQDQWUFQDJMK-SSTWWWIQSA-N;

CAS number : 362-07-2;

Drug name : Panzem;

Chemical formula : C19H26O3;

NSC code : 659853;

ChEBI ID : CHEBI:28955;

Codes from synonyms : 07274; CDR0000045058;

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04/05/2025


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