2-Methoxyestradiol

Preferred Label : 2-Methoxyestradiol;

NCIt synonyms : 2-Methoxy Estradiol; (17beta)-2-Methoxyestra-1,3,5(10)-triene-3,17-diol; 2ME2; 2-MeE2; 2-Methoxyestradiol; 2-MeOE2;

NCIt definition : An orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing endothelial cell proliferation and inducing endothelial cell apoptosis. This agent also inhibits tumor cell growth by binding to tubulin, resulting in antimitotic activity, and by inducing caspase activation, resulting in cell cycle arrest in the G2 phase, DNA fragmentation, and apoptosis. (NCI04);

Alternative definition : NCI-GLOSS: 2ME2. A drug derived from estrogen that belongs to the family of drugs called angiogenesis inhibitors. It prevents the formation of new blood vessels that tumors need in order to grow.;

UNII : 6I2QW73SR5;

InChIKey : CQOQDQWUFQDJMK-SSTWWWIQSA-N;

CAS number : 362-07-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 362-07-2 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Panzem;

Chemical formula : C19H26O3;

NSC code : 659853;

ChEBI ID : CHEBI:28955;

Codes from synonyms : 07274; CDR0000045058;

Details

Origin ID

C965;

UMLS CUI

C0046319;

Currated CISMeF NLP mapping
- 2-Methoxyestradiol [MeSH Descriptor]
- 2-methoxyestradiol [MeSH concept]
False automatic mappings
- 2-(methyl-11C)methoxyestradiol [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- 2-Methoxyestradiol [MeSH Descriptor]
- 2-methoxyestradiol [MeSH concept]
chemical_or_drug_affects_cell_type_or_tissue
- Endothelial Cell [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Microtubule Process [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Inhibition of Cell Proliferation [NCIt concept]
- Negative Regulation of Angiogenesis [NCIt concept]
- Negative Regulation of G2 Phase [NCIt concept]
- Negative Regulation of Mitosis [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Estrogen Receptor [NCIt concept]
- Tubulin [NCIt concept]

Keyword's position in hierarchy(ies) :

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