Preferred Label : Selective Estrogen Receptor Covalent Antagonist TQB3915;
NCIt definition : An orally bioavailable, selective and covalent antagonist of estrogen receptor alpha
(ERalpha; ERa; ESR1; nuclear receptor subfamily 3, group A, member 1; NR3A1), with
potential antineoplastic activity. Upon oral administration, selective estrogen receptor
covalent antagonist TQB3915 selectively and covalently binds to and inhibits the activity
of ERalpha. This inhibits the growth and survival of ERalpha-expressing cancer cells.
ERalpha, a nuclear hormone receptor often overexpressed and/or mutated in a variety
of cancer cell types, plays a key role in tumor cell proliferation and survival.;
Molecule name : TQB-3915; TQB 3915;
NCI Metathesaurus CUI : CL1793602;
Origin ID : C188362;
UMLS CUI : C5706495;
Semantic type(s)
- concept_is_in_subset
- has_target
