Ethinyl Estradiol

Preferred Label : Ethinyl Estradiol;

NCIt related terms : Feminone; Estinyl; Eticylol; Inestra; Diogyn E; Ethinoral; (17alpha)-19-Norpregna-1,3,5(10)-trien-20-yne-3,17-diol; Orestralyn; Diogyn-E; Lynoral; Ethinylestradiol;

NCIt definition : A semisynthetic estrogen. Ethinyl estradiol binds to the estrogen receptor complex and enters the nucleus, activating DNA transcription of genes involved in estrogenic cellular responses. This agent also inhibits 5-alpha reductase in epididymal tissue, which lowers testosterone levels and may delay progression of prostatic cancer. In addition to its antineoplastic effects, ethinyl estradiol protects against osteoporosis. In animal models, short-term therapy with this agent has been shown to provide long-term protection against breast cancer, mimicking the antitumor effects of pregnancy. (NCI04);

UNII : 423D2T571U;

InChIKey : BFPYWIDHMRZLRN-SLHNCBLASA-N;

CAS number : 57-63-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 57-63-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Eticylol; Inestra; Lynoral; Estinyl; Orestralyn; Feminone; Diogyn E; Ethinoral;

Chemical formula : C20H24O2;

NSC code : 10973;

ChEBI ID : CHEBI:4903;

Codes from synonyms : NSC0010973; 00400;

Details

Origin ID

C486;

UMLS CUI

C0015011;

CISMeF manual mappings
- Ethinylestradiol, ethinyloestradiol [ICD-11 Extension code]
Currated CISMeF NLP mapping
- Ethinylestradiol (substance) [SNOMED CT concept]
- ethinyl estradiol [Substance BNPC]
- ethinyl estradiol [MeSH Descriptor]
- ethinyl estradiol [MeSH concept]
- ethinyl estradiol [International Nonproprietary Name]
Semantic type(s)
- Hormone [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Ethinylestradiol (substance) [SNOMED CT concept]
- Ethinylestradiol, ethinyloestradiol [ICD-11 Extension code]
- Product containing ethinylestradiol (medicinal product) [SNOMED CT concept]
- ethinyl estradiol [Substance BNPC]
- ethinyl estradiol [International Nonproprietary Name]
- ethinyl estradiol [MeSH concept]
- ethinyl estradiol [MeSH Descriptor]
- ethinyl estradiol preparation, nos [SNOMED Notion]
- ethinylestradiol [ATC Code]
- ethinylestradiol [ATC Code]
Validated automatic mappings to BTNT
- ethinylestradiol [ATC Code]
- ethinylestradiol [ATC Code]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 1A2 [NCIt concept]
- Cytochrome P450 3A4 [NCIt concept]
- Cytochrome P450 3A5 [NCIt concept]
- Cytochrome P450 3A7 [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Estrogen Receptor [NCIt concept]
is_component_of_chemotherapy_regimen
- Cyclophosphamide/Doxorubicin/Ethinyl Estradiol/Fluorouracil/Leucovorin Calcium [NCIt concept]
- Ethinyl Estradiol/Norgestrel [NCIt concept]

Keyword's position in hierarchy(ies) :

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