Preferred Label : Selective Estrogen Receptor Degrader LX-039;
NCIt synonyms : SERD LX-039;
NCIt definition : An orally available selective estrogen receptor degrader/downregulator (SERD), with
potential antineoplastic activity. Upon oral administration, SERD LX-039 specifically
targets and binds to the estrogen receptor (ER) and induces a conformational change
that results in ER degradation. This prevents ER-mediated signaling and inhibits both
the growth and survival of ER-expressing cancer cells.;
Molecule name : LX 039; LX-039;
NCI Metathesaurus CUI : CL972812;
Origin ID : C168606;
UMLS CUI : C5238978;
Semantic type(s)
- concept_is_in_subset
- has_target
