Preferred Label : Selective Estrogen Receptor Degrader GDC-0927;
NCIt synonyms : SERD SRN-927; SERD RG6047; SERD GDC-0927;
NCIt related terms : GDC-0927;
NCIt definition : An orally available, nonsteroidal selective estrogen receptor degrader (SERD), with
potential antineoplastic activity. Upon oral administration, SERD GDC-0927 specifically
binds to the estrogen receptor (ER) and induces a conformational change that results
in the degradation of the receptor. This prevents ER-mediated signaling and inhibits
the growth and survival of ER-expressing cancer cells.;
UNII : ST9B0EMC0H;
CAS number : 2100830-77-9;
Molecule name : SRN-927; GDC-0927; SRN 927; RG-6047; GDC 0927; RG 6047;
Origin ID : C120037;
UMLS CUI : C3896765;
Semantic type(s)
- concept_is_in_subset
- has_target
