Preferred Label : Acolbifene Hydrochloride;
NCIt definition : The hydrochloride salt form of acolbifene, a fourth-generation estrogen receptor modulator
(SERM) with potential lipid lowering and antineoplastic activity. Acolbifene specifically
binds to estrogen receptors in responsive tissue, including liver, bone, breast, and
endometrium. The resulting ligand-receptor complex is translocated to the nucleus
where, depending on the tissue type, it promotes or suppresses the transcription of
estrogen-regulated genes, thereby exerting its agonistic or antagonistic effects.
Acolbifene acts as an estrogen antagonist in uterine and breast tissue, thereby blocking
the effects of estrogen in these tissues. This may inhibit tumor cell proliferation
in ER-positive tumor cells. This agent functions as an estrogen agonist in lipid metabolism,
thereby decreasing total and LDL cholesterol levels. In bone, it decreases bone resorption
and bone turnover and increases bone mineral density.;
Alternative definition : NCI-GLOSS: A substance being studied in the prevention of breast cancer in women at
high risk of breast cancer. Acolbifene hydrochloride binds to estrogen receptors in
the body and blocks the effects of estrogen in the breast. It is a type of selective
estrogen receptor modulator (SERM).;
UNII : KXC7811DBY;
InChIKey : BYQDPIXWTVEVEA-JMAPEOGHSA-N;
CAS number : 252555-01-4;
Chemical formula : C29H31NO4.ClH;
Codes from synonyms : CDR0000644298;
Origin ID : C65213;
UMLS CUI : C1879543;
Semantic type(s)
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_salt_form_of
