Selective Estrogen Receptor Degrader AZD9496

Preferred Label : Selective Estrogen Receptor Degrader AZD9496;

NCIt synonyms : (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic Acid; SERD AZD9496;

NCIt related terms : AZD-9496;

NCIt definition : An orally available selective estrogen receptor degrader (SERD), with potential antineoplastic activity. Upon administration, SERD AZD9496 binds to the estrogen receptor (ER) and induces a conformational change that results in the degradation of the receptor. This prevents ER-mediated signaling and inhibits the growth and survival of ER-expressing cancer cells.;

UNII : DA9P7LN909;

InChIKey : DFBDRVGWBHBJNR-BBNFHIFMSA-N;

CAS number : 1639042-08-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1639042-08-2 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : AZD 9496; AZD-9496;

Details

Origin ID

C122834;

UMLS CUI

C4053676;

Currated CISMeF NLP mapping
- AZD9496 [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- AZD9496 [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Estrogen Receptor [NCIt concept]

Keyword's position in hierarchy(ies) :

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