Preferred Label : Bazedoxifene;
NCIt synonyms : 1H-Indol-5-ol, 1-((4-(2-(hexahydro-1H-azepin-1-yl)ethoxy)phenyl)methyl)-2-(4-hydroxyphenyl)-3-methyl-; TSE-424;
NCIt definition : An indole derivative and third-generation selective estrogen receptor modulator (SERM)
with potential antineoplastic activity. Upon administration, bazedoxifene specifically
binds to estrogen receptors in responsive tissues, including liver, bone, breast,
and endometrium. The resulting ligand-receptor complex is translocated to the nucleus
where, depending on the tissue type, it either promotes or suppresses the transcription
of estrogen-regulated genes. Bazedoxifene acts as an estrogen antagonist in uterine
and breast tissue, thereby blocking the proliferative effects of estrogen-binding
to ER-positive cells in these tissues. Bazedoxifene functions as an estrogen agonist
in lipid metabolism, thereby decreasing total and LDL cholesterol levels. In bone,
it decreases bone resorption and bone turnover and increases bone mineral density.;
UNII : Q16TT9C5BK;
InChIKey : UCJGJABZCDBEDK-UHFFFAOYSA-N;
CAS number : 198481-32-2;
Molecule name : WAY 140424;
Chemical formula : C30H34N2O3;
Origin ID : C73598;
UMLS CUI : C2346970;
Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- has_salt_form
- has_target
- is_free_acid_or_base_form_of
