Preferred Label : Ethinyl Estradiol/Norethindrone;
NCIt synonyms : Ethinyl Estradiol-Norethindrone;
NCIt related terms : Ortho-Novum 1/35;
NCIt definition : An oral contraceptive formulation containing the semisynthetic estrogen, ethinyl estradiol,
combined with the synthetic progestin, norethindrone, with estrogenic and progestogenic
activities, respectively. Ethinyl estradiol binds to and activates intracellular estrogen
receptors found in the reproductive tract and other estrogen-responsive tissues. The
activated complex enters the nucleus, binds to the estrogen response elements on DNA,
activates the transcription of genes involved in the maintenance of the female reproductive
system, inhibits the release of follicle stimulating hormone (FSH) from the anterior
pituitary, and suppresses the development of the ovarian follicle. Norethindrone binds
to intracellular progesterone receptors in progesterone-responsive tissues, such as
the pituitary and those found in the reproductive system, and the activated ligand/receptor
complex interacts with specific progesterone response elements on DNA, which results
in the alteration in protein synthesis, the inhibition of ovulation, an increase in
cervical mucus production, the induction of the secretory phase of the endometrial
cycle, and the inhibition of luteinizing hormone (LH) release. The combination of
an estrogen with a progestin suppresses the hypothalamic-pituitary system and alters
the structure of the endometrium to discourage implantation.;
Drug name : Balziva; Gencept; Brevicon; Modicon; Norinyl; Nortrel; Ovcon; Norethin; Norcept-E; Ortho-Novum; Aranelle;
Codes from synonyms : 20492;
Origin ID : C29035;
UMLS CUI : C1260235;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
