Afimoxifene - CISMeF

Preferred Label : Afimoxifene;

NCIt synonyms : 4-Hydroxy-Tamoxifen; 4-Hydroxytamoxifen; 4-(1-(4-(2-(Dimethylamino)ethoxy)phenyl)-2-phenylbut-1-enyl)phenol; 4-OHT;

NCIt definition : A tamoxifen metabolite with both estrogenic and anti-estrogenic effects. Afimoxifene has a higher affinity for the estrogen receptor than tamoxifen, and functions as an antagonist in breast cancer cells.;

Alternative definition : NCI-GLOSS: A form of the drug tamoxifen that is made by the body after taking tamoxifen. It can also be made in the laboratory, and may help decrease breast density. A topical form of 4-hydroxytamoxifen is being studied in breast cancer screening.;

UNII : 17197F0KYM;

CAS number : 68392-35-8; 68047-06-3;

ChEBI ID : CHEBI:44616;

Codes from synonyms : CDR0000386195; 30509;

Details

Origin ID

C975;

UMLS CUI

C2347999;

Automatic exact mappings (from CISMeF team)
- 4-hydroxytamoxifen [MeSH concept]
Currated CISMeF NLP mapping
- 4-Hydroxy-Tamoxifen [LOINC component]
- afimoxifene [MeSH concept]
- afimoxifene [MeSH Supplementary Concept]
False automatic mappings
- 4,17 beta-dihydroxy-4-androstene-3-one [MeSH concept]
- 4,17 beta-dihydroxy-4-androstene-3-one [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- 4-Hydroxy-Tamoxifen [LOINC component]
- afimoxifene [MeSH concept]
- afimoxifene [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Estrogen Receptor [NCIt concept]

Keyword's position in hierarchy(ies) :

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