Giredestrant - CISMeF

Preferred Label : Giredestrant;

NCIt synonyms : Selective Estrogen Receptor Degrader GDC-9545; Selective Estrogen Receptor Downregulator GDC-9545; SERD GDC-9545;

NCIt definition : An orally available selective estrogen receptor degrader/downregulator (SERD), with potential antineoplastic activity. Upon oral administration, giredestrant specifically targets and binds to the estrogen receptor (ER) and induces a conformational change that promotes ER degradation. This prevents ER-mediated signaling and inhibits both the growth and survival of ER-expressing cancer cells.;

UNII : 28P3DU6DB3;

InChIKey : GQCXHIKRWBIQMD-AKJBCIBTSA-N;

CAS number : 1953133-47-5;

Molecule name : RG6171; GDC-49545; GDC 9545;

NCI Metathesaurus CUI : CL545029;

Details

Origin ID

C147030;

UMLS CUI

C5418237;

Currated CISMeF NLP mapping
- giredestrant [MeSH concept]
- giredestrant [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- giredestrant [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Estrogen Receptor [NCIt concept]

Keyword's position in hierarchy(ies) :

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