NCIt definition : The tartrate salt form of metoprolol, a cardioselective competitive beta-1 adrenergic
receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic
activity. Metoprolol tartrate antagonizes beta 1-adrenergic receptors in the myocardium,
thereby reducing the rate and force of myocardial contraction, and consequently a
diminished cardiac output. This agent may also reduce the secretion of renin with
subsequent reduction in levels of angiotensin II thus decreasing sympathetic activation,
including vasoconstriction, aldosterone secretion.;