Captopril - CISMeF

Preferred Label : Captopril;

NCIt synonyms : (S)-1-(3-Mercapto-2-methyl-1-oxopropyl)-L-proline;

NCIt definition : A sulfhydryl-containing analog of proline with antihypertensive activity and potential antineoplastic activity. Captopril competitively inhibits angiotensin converting enzyme (ACE), thereby decreasing levels of angiotensin II, increasing plasma renin activity, and decreasing aldosterone secretion. This agent may also inhibit tumor angiogenesis by inhibiting endothelial cell matrix metalloproteinases (MMPs) and endothelial cell migration. Captopril may also exhibit antineoplastic activity independent of effects on tumor angiogenesis. (NCI04);

Alternative definition : NCI-GLOSS: A drug used to treat high blood pressure that is also being studied in the prevention of side effects caused by radiation therapy used in the treatment of cancer. It belongs to the family of drugs called ACE inhibitors.;

UNII : 9G64RSX1XD;

InChIKey : FAKRSMQSSFJEIM-RQJHMYQMSA-N;

CAS number : 62571-86-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 62571-86-2 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Capoten;

Chemical formula : C9H15NO3S;

NSC code : 719847;

ChEBI ID : CHEBI:3380;

Codes from synonyms : 06714; CDR0000044878;

Details

Origin ID

C340;

UMLS CUI

C0006938;

Automatic exact mappings (from CISMeF team)
- Captopril [LOINC Challenge]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Captopril [ICD-11 Extension code]
- Captopril [LOINC Challenge]
- Captopril [LOINC component]
- Captopril (substance) [SNOMED CT concept]
- Product containing captopril (medicinal product) [SNOMED CT concept]
- captopril [ATC Code]
- captopril [Substance BNPC]
- captopril [SNOMED Notion]
- captopril [MeSH concept]
- captopril [MeSH Descriptor]
Validated automatic mappings to BTNT
- captopril [ATC Code]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 2D6 [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Captopril/Tissue Plasminogen Activator [NCIt concept]

Keyword's position in hierarchy(ies) :

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