" /> Amitriptyline - CISMeF





Preferred Label : Amitriptyline;

NCIt synonyms : Amitriptyline Base;

NCIt definition : A derivative of dibenzocycloheptadiene and a tricyclic antidepressant. Amitriptyline inhibits the re-uptake of norepinephrine and serotonin by the presynaptic neuronal membrane in the central nervous system (CNS), thereby increasing the synaptic concentration of norepinephrine and serotonin. Due to constant stimulation to these receptors, amitriptyline may produce a downregulation of adrenergic and serotonin receptors, which may contribute to the antidepressant activity.;

Alternative definition : NCI-GLOSS: A drug that is used to treat depression and may be given to treat anxiety, sleep disorders, and pain. It is also being studied in an oral or gel form in the treatment of nerve pain caused by chemotherapy. Amitriptyline is a type of tricyclic antidepressant.;

UNII : 1806D8D52K;

InChIKey : KRMDCWKBEZIMAB-UHFFFAOYSA-N;

CAS number : 50-48-6;

Chemical formula : C20H23N;

ChEBI ID : CHEBI:2666;

Codes from synonyms : CDR0000557356;

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30/07/2025


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