NCIt definition : A derivative of dibenzocycloheptadiene and a tricyclic antidepressant. Amitriptyline
inhibits the re-uptake of norepinephrine and serotonin by the presynaptic neuronal
membrane in the central nervous system (CNS), thereby increasing the synaptic concentration
of norepinephrine and serotonin. Due to constant stimulation to these receptors, amitriptyline
may produce a downregulation of adrenergic and serotonin receptors, which may contribute
to the antidepressant activity.;
Alternative definition : NCI-GLOSS: A drug that is used to treat depression and may be given to treat anxiety,
sleep disorders, and pain. It is also being studied in an oral or gel form in the
treatment of nerve pain caused by chemotherapy. Amitriptyline is a type of tricyclic
antidepressant.;