Haloperidol - CISMeF

Preferred Label : Haloperidol;

NCIt synonyms : 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone;

NCIt related terms : McN-JR-1625; Haldol; R-1625; R 1625;

NCIt definition : A phenylbutylpiperadine derivative with antipsychotic, neuroleptic, and antiemetic activities. Haloperidol competitively blocks postsynaptic dopamine (D2) receptors in the mesolimbic system of the brain, thereby eliminating dopamine neurotransmission and leading to antidelusionary and antihallucinagenic effects. Antagonistic activity mediated through D2 dopamine receptors in the chemoreceptive trigger zone (CTZ) accounts for its antiemetic activity.;

Alternative definition : NCI-GLOSS: A drug used to treat certain mental and neurological disorders. It is also being studied in the treatment of nausea and vomiting caused by some cancer treatments. It is a type of antiemetic and a type of antipsychotic.;

UNII : J6292F8L3D;

InChIKey : LNEPOXFFQSENCJ-UHFFFAOYSA-N;

CAS number : 52-86-8;

Drug name : Haldol;

Molecule name : McN-JR-1625; R-1625;

Chemical formula : C21H23ClFNO2;

NSC code : 170973;

ChEBI ID : CHEBI:5613;

Codes from synonyms : CDR0000572159; NSC0615296; NSC0170973; 00482; CDR0000476306; 253;

Details

Origin ID

C537;

UMLS CUI

C0018546;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Haloperidol [ICD-11 Extension code]
- Haloperidol [LOINC component]
- Haloperidol (substance) [SNOMED CT concept]
- Product containing haloperidol (medicinal product) [SNOMED CT concept]
- haloperidol [ATC Code]
- haloperidol [Substance BNPC]
- haloperidol [MeSH concept]
- haloperidol [MeSH Descriptor]
- haloperidol [SNOMED Notion]
Validated automatic mappings to BTNT
- haloperidol [ATC Code]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 1A2 [NCIt concept]
- Cytochrome P450 2D6 [NCIt concept]
- Cytochrome P450 3A4 [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_salt_form
- Haloperidol Decanoate [NCIt concept]
- Haloperidol Lactate [NCIt concept]
has_target
- D(2) Dopamine Receptor [NCIt concept]
is_free_acid_or_base_form_of
- Haloperidol Decanoate [NCIt concept]
- Haloperidol Lactate [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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