NCIt definition : The decanoate ester of haloperidol, a phenylbutylpiperadine derivative with antipsychotic,
neuroleptic and antiemetic effects. Haloperidol competitively blocks postsynaptic
dopamine (D2) receptors in the mesolimbic system of the brain leading to anti-delusionary
and anti-hallucinogenic effects. The antagonistic activity mediated through D2 dopamine
receptors in the chemoreceptive trigger zone (CTZ) account for its antiemetic activity.;