Preferred Label : D(2) Dopamine Receptor;
NCIt synonyms : DRD2 Receptor; DRD2; Dopamine D2 Receptor; Dopamine Receptor-D2;
NCIt related terms : DOPAMINE RECEPTOR D2;
NCIt definition : D(2) dopamine receptor (443 aa, 51 kDa) is encoded by the human DRD2 gene. This protein
plays a role in dopamine binding, angiogenesis inhibition, and receptor signaling.;
Alternative definition : CDISC: An antigen encoded by the DRD2 gene and is involved in dopamine binding, angiogenesis
inhibition, and receptor signaling. It can be considered as an autoantigen and is
commonly associated with autoimmune encephalitic syndromes and neuropsychiatric abnormalities.;
NCIt note : Neurotransmission mediated by the Dopamine D2 Receptor (DRD2) plays a key role in
the control of movement, in reward and reinforcement mechanisms in psychiatric disorders,
and in the neuromodulation of appetitive behaviors. Acting through D2 dopamine receptors,
dopamine specifically inhibits the vascular permeabilizing and angiogenic activities
of VEGF by inducing endocytosis of VEGF receptor 2, preventing VEGF binding, receptor
phosphorylation, and signaling. (OMIM);
Origin ID : C17292;
UMLS CUI : C3659270;
Currated CISMeF NLP mapping
- OMIM relation
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- gene_encodes_gene_product
- gene_product_has_associated_anatomy
- gene_product_has_biochemical_function
- gene_product_has_chemical_classification
- gene_product_has_structural_domain_or_motif
- gene_product_is_element_in_pathway
- gene_product_malfunction_associated_with_disease
- gene_product_plays_role_in_biological_process
- is_target
