NCIt definition : A substituted benzamide and a derivative of para-aminobenzoic acid (PABA) that is
structurally related to procainamide, with gastroprokinetic and antiemetic effects.
Metoclopramide exerts its prokinetic effect by antagonizing dopamine mediated relaxation
effect on gastrointestinal smooth muscle. This enhances the response of the gastrointestinal
smooth muscle to cholinergic stimulation, thereby leading to an increase of gastric
emptying into the intestines. Metoclopramide may also strengthen the lower esophagus
sphincter, thereby preventing acid reflux. This agent antagonizes D2 dopamine receptors
in chemoreceptive trigger zone (CTZ) of the medulla, thereby preventing nausea and
vomiting.;
Alternative definition : NCI-GLOSS: A drug that increases the motility (movements and contractions) of the
stomach and upper intestine. It is used to treat certain stomach problems and nausea
and vomiting caused by chemotherapy. It is a type of antiemetic and a type of motility
agent.;