Olanzapine - CISMeF

Preferred Label : Olanzapine;

NCIt synonyms : 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno(2,3-b)(1,5)benzodiazepine;

NCIt related terms : Zyprexa; Zyprexa Zydis;

NCIt definition : A synthetic derivative of thienobenzodiazepine with antipsychotic, antinausea, and antiemetic activities. As a selective monoaminergic antagonist, olanzapine binds with high affinity binding to the following receptors: serotoninergic, dopaminergic, muscarinic M1-5, histamine H1, and alpha-1-adrenergic receptors; it binds weakly to gamma-aminobutyric acid type A, benzodiazepine, and beta-adrenergic receptors. The antinausea and antiemetic effects of this agent appear to be due to the blockade of 5-HT2 and 5-HT3 receptors for serotonin. Although its exact mechanism of action in schizophrenia is unknown, it has been proposed that olanzapine's antipsychotic activity is mediated through antagonism to dopamine D2 receptors with rapid ligand-receptor dissociation kinetics that help to minimize extrapyramidal symptoms (EPS). Olanzapine may also stimulate appetite.;

Alternative definition : NCI-GLOSS: A drug used to treat certain mental disorders. It is also being studied in the treatment of nausea and vomiting caused by some cancer treatments. It is a type of antipsychotic and a type of monoamine antagonist.;

UNII : N7U69T4SZR;

InChIKey : KVWDHTXUZHCGIO-UHFFFAOYSA-N;

CAS number : 132539-06-1;

Drug name : Zyprexa; Zyprexa Zydis;

Molecule name : LY 170053;

Chemical formula : C17H20N4S;

ChEBI ID : CHEBI:7735;

Codes from synonyms : CDR0000572213; CDR0000572212; CDR0000476310; 365;

Origin ID

C47639;

UMLS CUI

C0171023;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- OLANZapine [LOINC component]
- Olanzapine [MeSH Descriptor]
- Olanzapine [ICD-11 Extension code]
- Olanzapine (substance) [SNOMED CT concept]
- Product containing olanzapine (medicinal product) [SNOMED CT concept]
- olanzapine [ATC Code]
- olanzapine [Substance BNPC]
- olanzapine [MeSH concept]
Validated automatic mappings to BTNT
- olanzapine [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

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