Donepezil Hydrochloride

Preferred Label : Donepezil Hydrochloride;

NCIt synonyms : 1-Benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine Hydrochloride; Donepezil;

NCIt definition : The hydrochloride salt of a piperidine derivative with neurocognitive-enhancing activity. Donepezil reversibly inhibits acetylcholinesterase, thereby blocking the hydrolysis of the neurotransmitter acetylcholine and, consequently, increasing its activity. This agent may improve neurocognitive function in Alzheimer's disease, reduce sedation associated with opioid treatment of cancer pain, and improve neurocognitive function in patients who have received radiation therapy for primary brain tumors or brain metastases.;

UNII : 3O2T2PJ89D;

InChIKey : XWAIAVWHZJNZQQ-UHFFFAOYSA-N;

CAS number : 120011-70-3; 142057-77-0;

Drug name : Aricept;

Molecule name : E-2020;

Chemical formula : C24H29NO3.HCl;

ChEBI ID : CHEBI:4696;

Details

Origin ID

C2603;

UMLS CUI

C0771848;

Automatic exact mappings (from CISMeF team)
- Donepezil [ICD-11 Extension code]
- donepezil [Substance BNPC]
See also inter- (CISMeF)
- Donepezil hydrochloride (product) [Inactive SNOMED CT concept]
- Product containing donepezil (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
Validated automatic mappings to NTBT
- Donepezil [LOINC component]
- Donepezil [MeSH Descriptor]
- Donepezil [SMS substance]
- Donepezil (substance) [SNOMED CT concept]
- donepezil [MeSH concept]
- donepezil [ATC Code]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 2D6 [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_free_acid_or_base_form
- Donepezil [NCIt concept]
has_target
- Acetylcholinesterase [NCIt concept]
is_component_of_chemotherapy_regimen
- Donepezil/Vitamin E [NCIt concept]
is_salt_form_of
- Donepezil [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients