" /> Acetylcholinesterase - CISMeF





Preferred Label : Acetylcholinesterase;

NCIt synonyms : Acetylcholine Acetylhydrolase; AChE; EC 3.1.1.7;

NCIt definition : Acetylcholinesterase (614 aa, 68 kDa) is encoded by the human ACHE gene. This protein plays a role in acetylcholine hydrolysis, neuronal apoptosis and the structure of the Cartwright (Yt) blood group antigen.;

NCIt note : Tailed ACHE is the UniProt canonical form of acetylcholinesterase.; Acetylcholinesterase exists in multiple molecular forms which differ in their oligomeric assembly and mode of cell attachment to the cell surface. Tailed ACHE (ACHE-T; synaptic ACHE; ACHE-S), is the hydrophilic species, which can form monomers or dimers and can form disulfide-linked tetramers when associated with collagenous or lipid-containing anchoring proteins that attach them to the basal lamina or to cell membranes. ACHE-T is most frequently expressed in brain and muscle cells. Hydrophobic ACHE (ACHE-H; erythrocytic ACHE; ACHE-E) has a cleavable hydrophobic peptide with a C-terminal GPI-anchor site and is expressed as disulfide linked dimers in erythrocyte membranes. The readthrough ACHE (read-through ACHE; ACHE-R) is a rare transcript that may be monomeric and appears to be induced by acute stress responses in the brain. ACHE-R may counteract neuronal apoptosis and the neurodeterioration that ACHE-T can promote during abnormal cholinergic neurotransmission; therefore, ACHE-R may prevent the shift from transient, acute stress to progressive neurological disease.(UniProt, FASEB J. 2003;17:214-22 and PNAS. 2000;97:8647-8652.);

PubMed : 12554700; 10890884;

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29/04/2024


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