NCIt definition : An extended-release (ER) formulation of the hydrobromide salt form of galantamine,
a tertiary alkaloid obtained synthetically or naturally from the bulbs and flowers
of Narcissus and several other genera of the Amaryllidaceae family, with anticholinesterase
and neurocognitive-enhancing activities. Upon administration, galantamine competitively
and reversibly inhibits acetylcholinesterase, thereby increasing the concentration
and enhancing the action of acetylcholine (Ach). In addition, galantamine is a ligand
for nicotinic acetylcholine receptors, which may increase the presynaptic release
of Ach and activate postsynaptic receptors. This agent may improve neurocognitive
function in mild and moderate Alzheimer's disease and may, through its Ach stimulating
effect on nicotinic receptors, help quit smoking and reduce abstinence-induced cognitive
symptoms that promote smoking relapse.;