Preferred Label : Donepezil;

MeSH definition : An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.;

MeSH hyponym : E2020; E-2020; 1-Benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine hydrochloride;

MeSH CAS label : 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-((1-(phenylmethyl)-4-piperidinyl)methyl)-;

MeSH Related Number : 120011-70-3 (Donepezil); 3O2T2PJ89D;

Wikipedia link : https://en.wikipedia.org/wiki/Donepezil;

UNII : 8SSC91326P;

Details


Main resources

You can consult :

An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.

https://ansm.sante.fr/informations-de-securite/specialites-a-base-de-donepezil-aricept-et-generiques-mise-a-jour-de-linformation-produit-concernant-les-troubles-de-la-conduction-cardiaque-incluant-lallongement-de-lintervalle-qtc-et-les-torsades-de-pointes
2022
false
false
false
France
French
pharmacovigilance note
Donepezil
donepezil
administration, oral
long qt syndrome
torsades de pointes
risk factors
cholinesterase inhibitors

---
https://dumas.ccsd.cnrs.fr/dumas-02971517
2020
France
dissertations, academic
E 2020
medical computer science
mobility, nos
Intertrochanteric fracture
data collection
health status
telemedicine
mobile health
Applications
Applications
mobile applications
Applications
Donepezil
medical informatics

---
https://www.has-sante.fr/portail/jcms/c_2851234/fr/donepezil-biogaran
2018
false
false
false
false
France
French
evaluation of the transparency committee
indans
piperidines
Donepezil

---
https://www.has-sante.fr/portail/jcms/c_2851228/fr/aricept
2018
false
false
false
false
France
French
evaluation of the transparency committee
Aricept
indans
piperidines
Donepezil

---
https://www.has-sante.fr/portail/jcms/c_2679466/fr/medicaments-de-la-maladie-d-alzheimer-un-interet-medical-insuffisant-pour-justifier-leur-prise-en-charge-par-la-solidarite-nationale
2016
false
false
false
France
French
drug evaluation
alzheimer disease
treatment outcome
evaluation of the transparency committee
donepezil hydrochloride
donepezil
cholinesterase inhibitors
cholinesterase inhibitors
insurance, health, reimbursement
alzheimer disease
memantine
memantine
memantine hydrochloride
receptors, n-methyl-d-aspartate
excitatory amino acid antagonists
excitatory amino acid antagonists
administration, oral
administration, cutaneous
Rivastigmine
rivastigmine
galantamine
Galanthamine Hydrobromide
quality of life
galantamine
indans
piperidines
Donepezil

---
http://www.has-sante.fr/portail/jcms/c_2681001/fr/aricept
http://www.has-sante.fr/portail/jcms/c_2681001/fr/aricept-donepezil-antagoniste-non-competitif-des-recepteurs-nmda
2016
false
false
false
France
French
evaluation of the transparency committee
alzheimer disease
treatment outcome
guidelines for drug use
administration, oral
donepezil
donepezil hydrochloride
insurance, health, reimbursement
aged
drug interactions
receptors, n-methyl-d-aspartate
Donepezil

---
https://canadiensensante.gc.ca/recall-alert-rappel-avis/hc-sc/2015/43469a-fra.php
2015
false
false
false
Canada
French
English
pharmacovigilance note
donepezil
alzheimer disease
rhabdomyolysis
neuroleptic malignant syndrome
administration, oral
risk
risk factors
drug monitoring
Donepezil

---
http://www.meddispar.fr/Medicaments/DONEPEZIL-KRKA-10-B-28/(type)/letter/(value)/D/(cip)/3400921709247
2014
true
France
French
drug information
donepezil hydrochloride
donepezil
drugs, generic
administration, oral
legislation, drug
drug prescriptions
indans
piperidines
Donepezil

---
http://www.meddispar.fr/Medicaments/DONEPEZIL-KRKA-5-B-28/(type)/letter/(value)/D/(cip)/3400921708707
2014
true
France
French
drug information
donepezil hydrochloride
donepezil
administration, oral
drugs, generic
legislation, drug
drug prescriptions
indans
piperidines
Donepezil

---
http://www.meddispar.fr/Medicaments/DONEPEZIL-CRISTERS-10-B-28/(type)/letter/(value)/D/(cip)/3400926607005
2013
France
French
drug information
donepezil hydrochloride
donepezil
drugs, generic
administration, oral
legislation, drug
drug prescriptions
indans
piperidines
Donepezil

---
http://www.meddispar.fr/Medicaments/DONEPEZIL-CRISTERS-5-B-28/(type)/letter/(value)/D/(cip)/3400926606343
2013
France
French
drug information
donepezil hydrochloride
donepezil
administration, oral
drugs, generic
legislation, drug
drug prescriptions
indans
piperidines
Donepezil

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=67989646
2013
France
summary of product characteristics
tablets
donepezil hydrochloride
Donepezil

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=61129173
2013
France
summary of product characteristics
tablets
donepezil hydrochloride
Donepezil

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=62793519
2013
France
summary of product characteristics
tablets
donepezil hydrochloride
Donepezil

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=64686163
2013
France
summary of product characteristics
donepezil hydrochloride
tablets
Donepezil

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=68474250
2013
France
summary of product characteristics
tablets
donepezil hydrochloride
Donepezil

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=61768776
2013
France
summary of product characteristics
tablets
donepezil hydrochloride
Donepezil

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=61842034
2012
France
summary of product characteristics
package leaflet
tablets
Donepezil

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=68369527
2012
France
summary of product characteristics
package leaflet
tablets
Donepezil

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=65823597
2012
France
package leaflet
summary of product characteristics
tablets
health
Donepezil

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=66014082
2012
France
package leaflet
summary of product characteristics
tablets
health
Donepezil

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=64267973
2012
France
summary of product characteristics
package leaflet
tablets
Donepezil

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=60468103
2012
France
summary of product characteristics
package leaflet
tablets
Donepezil

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=60756963
2012
France
summary of product characteristics
package leaflet
tablets
Donepezil

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=66317873
2012
France
summary of product characteristics
package leaflet
tablets
Donepezil

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=63688528
2012
France
summary of product characteristics
package leaflet
donepezil hydrochloride
tablets
Donepezil

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=61400781
2012
France
summary of product characteristics
package leaflet
tablets
donepezil hydrochloride
Donepezil

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=67257660
2012
France
summary of product characteristics
package leaflet
donepezil hydrochloride
tablets
Donepezil

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=64024786
2012
France
summary of product characteristics
package leaflet
tablets
donepezil hydrochloride
Donepezil

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=60569892
2012
France
summary of product characteristics
package leaflet
tablets
donepezil hydrochloride
Donepezil

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=65345072
2012
France
summary of product characteristics
package leaflet
tablets
donepezil hydrochloride
Donepezil

---
http://www.meddispar.fr/Medicaments/DONEPEZIL-ALTER-10-B-28/(type)/letter/(value)/D/(cip)/3400949939374
2012
France
French
drug information
indans
piperidines
donepezil hydrochloride
donepezil
administration, oral
continuity of patient care
drugs, generic
drug prescriptions
legislation, drug
Donepezil

---
http://www.meddispar.fr/Medicaments/DONEPEZIL-ARROW-GENERIQUES-10-B-28/(type)/letter/(value)/D/(cip)/3400938999464
2012
France
French
drug information
indans
piperidines
drugs, generic
administration, oral
continuity of patient care
drug prescriptions
legislation, drug
donepezil hydrochloride
donepezil
Donepezil

---
http://www.meddispar.fr/Medicaments/DONEPEZIL-ARROW-GENERIQUES-5-B-28/(type)/letter/(value)/D/(cip)/3400938998634
2012
France
French
drug information
indans
piperidines
donepezil hydrochloride
donepezil
administration, oral
drug prescriptions
legislation, drug
continuity of patient care
drugs, generic
Donepezil

---
http://www.meddispar.fr/Medicaments/DONEPEZIL-PFIZER-10-B-28/(type)/letter/(value)/D/(cip)/3400921825190
2012
France
French
drug information
indans
piperidines
donepezil hydrochloride
donepezil
drugs, generic
administration, oral
continuity of patient care
drug prescriptions
legislation, drug
Donepezil

---
http://www.meddispar.fr/Medicaments/DONEPEZIL-TEVA-SANTE-5-B-28/(type)/letter/(value)/D/(cip)/3400938997804
2012
France
French
drug information
indans
piperidines
donepezil hydrochloride
donepezil
drugs, generic
administration, oral
continuity of patient care
drug prescriptions
legislation, drug
Donepezil

---
http://www.meddispar.fr/Medicaments/DONEPEZIL-EG-10-B-28/(type)/letter/(value)/D/(cip)/3400949362479
2012
France
French
drug information
indans
piperidines
donepezil hydrochloride
donepezil
drugs, generic
administration, oral
continuity of patient care
drug prescriptions
legislation, drug
Donepezil

---
http://www.meddispar.fr/Medicaments/DONEPEZIL-EG-5-B-28/(type)/letter/(value)/D/(cip)/3400949361649
2012
France
French
drug information
indans
piperidines
donepezil hydrochloride
donepezil
drugs, generic
administration, oral
continuity of patient care
drug prescriptions
legislation, drug
Donepezil

---
http://www.meddispar.fr/Medicaments/DONEPEZIL-PFIZER-5-B-28/(type)/letter/(value)/D/(cip)/3400921824889
2012
France
French
drug information
indans
piperidines
donepezil hydrochloride
donepezil
drugs, generic
administration, oral
continuity of patient care
drug prescriptions
legislation, drug
Donepezil

---
http://www.meddispar.fr/DONEPEZIL-SANDOZ-10-B-28/(type)/letter/(value)/D/(cip)/3400922043272
2012
France
French
drug information
indans
piperidines
donepezil hydrochloride
donepezil
drugs, generic
administration, oral
continuity of patient care
drug prescriptions
legislation, drug
Donepezil

---
http://www.meddispar.fr/DONEPEZIL-SANDOZ-5-B-28/(type)/letter/(value)/D/(cip)/3400922042381
2012
France
French
drug information
indans
piperidines
donepezil
donepezil hydrochloride
drugs, generic
administration, oral
drug prescriptions
legislation, drug
continuity of patient care
Donepezil

---
http://www.meddispar.fr/Medicaments/DONEPEZIL-TEVA-10-B-28/(type)/letter/(value)/D/(cip)/3400938186178
2012
France
French
drug information
indans
piperidines
donepezil hydrochloride
administration, oral
drugs, generic
legislation, drug
drug prescriptions
donepezil
Donepezil

---
http://www.meddispar.fr/Medicaments/DONEPEZIL-TEVA-5-B-28/(type)/letter/(value)/D/(cip)/3400938144017
2012
France
French
drug information
donepezil hydrochloride
drugs, generic
drug prescriptions
legislation, drug
administration, oral
donepezil
indans
piperidines
Donepezil

---
http://www.meddispar.fr/Medicaments/DONEPEZIL-SANDOZ-10-B-28/(type)/letter/(value)/D/(cip)/3400938902181
2012
France
French
drug information
donepezil hydrochloride
indans
piperidines
drugs, generic
administration, oral
drug prescriptions
legislation, drug
donepezil
Donepezil

---
http://www.meddispar.fr/Medicaments/DONEPEZIL-SANDOZ-5-B-28/(type)/letter/(value)/D/(cip)/3400938901641
2012
France
French
drug information
donepezil hydrochloride
administration, oral
drugs, generic
drug prescriptions
legislation, drug
donepezil
indans
piperidines
Donepezil

---
http://www.meddispar.fr/Medicaments/DONEPEZIL-ZYDUS-5-B-28/(type)/letter/(value)/D/(cip)/3400939856117
2012
France
French
indans
piperidines
donepezil hydrochloride
administration, oral
drug prescriptions
legislation, drug
drugs, generic
donepezil
drug information
Donepezil

---
http://www.meddispar.fr/Medicaments/DONEPEZIL-ZYDUS-10-B-28/(type)/letter/(value)/D/(cip)/3400939857695
2012
France
French
drug information
indans
piperidines
donepezil hydrochloride
administration, oral
drugs, generic
donepezil
drug prescriptions
legislation, drug
Donepezil

---
http://www.has-sante.fr/portail/jcms/c_1231960/place-des-medicaments-du-traitement-symptomatique-de-la-maladie-dalzheimer
http://www.has-sante.fr/portail/upload/docs/application/pdf/2012-03/questions_alzheimer_fiche_bum_mars_2012.pdf
2012
true
France
French
guidelines for drug use
practice guideline
Rivastigmine
donepezil
Galanthamine Hydrobromide
rivastigmine
galantamine
alzheimer disease
cholinesterase inhibitors
donepezil hydrochloride
nootropic agents
administration, oral
administration, cutaneous
transdermal patch
indans
piperidines
acetylcholinesterase
butyrylcholinesterase
drug evaluation
treatment outcome
Delayed-Action preparations
galantamine
excitatory amino acid antagonists
memantine
memantine hydrochloride
memantine
receptors, n-methyl-d-aspartate
evaluation of the transparency committee
Donepezil

---
http://www.meddispar.fr/Medicaments/DONEPEZIL-ZENTIVA-10-B-28/(type)/letter/(value)/D/(cip)/3400941990564
2012
France
French
drug information
indans
piperidines
donepezil hydrochloride
donepezil
drug prescriptions
legislation, drug
drugs, generic
administration, oral
Donepezil

---
http://www.meddispar.fr/Medicaments/DONEPEZIL-ZENTIVA-5-B-28/(type)/letter/(value)/D/(cip)/3400941989964
2012
France
French
drug information
indans
piperidines
donepezil hydrochloride
donepezil
drug prescriptions
legislation, drug
drugs, generic
Donepezil

---
http://www.meddispar.fr/Medicaments/DONEPEZIL-RANBAXY-10-B-28/(type)/letter/(value)/D/(cip)/3400938706123
2012
France
French
drug information
indans
piperidines
drugs, generic
administration, oral
drug prescriptions
legislation, drug
donepezil
donepezil hydrochloride
Donepezil

---
http://www.meddispar.fr/Medicaments/DONEPEZIL-RANBAXY-5-B-28/(type)/letter/(value)/D/(cip)/3400938705171
2012
France
French
drug information
indans
piperidines
administration, oral
drugs, generic
drug prescriptions
legislation, drug
donepezil
donepezil hydrochloride
Donepezil

---
http://www.meddispar.fr/Medicaments/DONEPEZIL-TEVA-SANTE-10-B-28/(type)/letter/(value)/D/(cip)/3400938999174
2012
France
French
drug information
drugs, generic
administration, oral
donepezil
drug prescriptions
legislation, drug
donepezil hydrochloride
indans
piperidines
Donepezil

---
http://www.has-sante.fr/portail/display.jsp?id=c_593193
http://www.has-sante.fr/portail/jcms/c_1022283/aricept
http://www.has-sante.fr/portail/upload/docs/application/pdf/2011-02/aricept_-_ct-9398.pdf
2011
false
France
French
tablets
nootropic agents
cholinesterase inhibitors
alzheimer disease
donepezil
insurance, health, reimbursement
donepezil hydrochloride
evaluation of the transparency committee
Donepezil

---
http://www.has-sante.fr/portail/jcms/c_1117852/aricept
http://www.has-sante.fr/portail/upload/docs/application/pdf/2011-11/aricept_19-10-2011_avis_10755.pdf
2011
false
France
French
evaluation of the transparency committee
administration, oral
insurance, health, reimbursement
treatment outcome
donepezil
cholinesterase inhibitors
alzheimer disease
donepezil hydrochloride
Donepezil

---
http://www.has-sante.fr/portail/jcms/c_1191345/aricept-donepezil-exelon-rivastigmine-reminyl-galantamine-ebixa-memantine-medicaments-du-traitement-symptomatique-de-la-maladie-dalzheimer
2011
false
France
French
guidelines for drug use
evaluation of the transparency committee
Rivastigmine
memantine hydrochloride
Galanthamine Hydrobromide
galantamine
donepezil hydrochloride
rivastigmine
memantine
receptors, n-methyl-d-aspartate
excitatory amino acid antagonists
memantine
galantamine
treatment outcome
cholinesterase inhibitors
administration, oral
donepezil
insurance, health, reimbursement
administration, cutaneous
transdermal patch
Delayed-Action preparations
alzheimer disease
RivastigmineTartrate
Donepezil

---
http://www.cochrane.org/fr/CD006104
2010
false
United Kingdom
France
French
review of literature
Cognitive Dysfunction
treatment outcome
nootropic agents
french abstract
Donepezil

---
http://www.has-sante.fr/portail/upload/docs/application/pdf/qestions_reponses_alzheimer_031007_2007_10_03__16_17_35_610.pdf
http://www.has-sante.fr/portail/upload/docs/application/pdf/synthese_avis_alzheimer_031007_2007_10_05__10_24_44_497.pdf
http://www.has-sante.fr/portail/jcms/c_594403/quelle-place-pour-les-medicaments-anti-alzheimer-dans-la-prise-en-charge-des-patients
2009
false
France
French
Rivastigmine
donepezil
galantamine
nootropic agents
galantamine
rivastigmine
memantine
memantine
guidelines for drug use
evaluation of the transparency committee
RivastigmineTartrate
alzheimer disease
indans
piperidines
treatment outcome
cholinesterase inhibitors
donepezil hydrochloride
Galanthamine Hydrobromide
memantine hydrochloride
Donepezil

---
http://www.meddispar.fr/medicaments/3730644
2008
France
French
piperidines
tablets
administration, oral
continuity of patient care
indans
drug prescriptions
legislation, drug
donepezil
donepezil hydrochloride
drug information
Donepezil

---
http://www.meddispar.fr/medicaments/3444909
2008
France
French
administration, oral
continuity of patient care
drug monitoring
indans
drug prescriptions
legislation, drug
tablets
donepezil
donepezil hydrochloride
drug information
Donepezil

---
http://www.meddispar.fr/medicaments/3730609
2008
France
French
piperidines
administration, oral
continuity of patient care
drug monitoring
indans
drug prescriptions
legislation, drug
tablets
donepezil
donepezil hydrochloride
drug information
Donepezil

---
http://www.meddispar.fr/medicaments/3444950
2008
France
French
piperidines
administration, oral
continuity of patient care
drug monitoring
indans
drug prescriptions
legislation, drug
tablets
donepezil
donepezil hydrochloride
drug information
Donepezil

---
https://minerva-ebp.be/fr/article/830
2005
false
false
minerva-ebm.be
Belgium
French
alzheimer disease
treatment outcome
memantine
excitatory amino acid antagonists
cholinesterase inhibitors
nootropic agents
drug therapy, combination
indans
piperidines
critical appraisal or critical reading
Donepezil

---
https://minerva-ebp.be/fr/article/751
2005
false
false
minerva-ebm.be
Belgium
French
alzheimer disease
cholinesterase inhibitors
nootropic agents
treatment outcome
Cost-Benefit analysis
indans
piperidines
critical appraisal or critical reading
Donepezil

---
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03/05/2025


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