Preferred Label : neuroleptic malignant syndrome;

Obsolete resource : false;

MeSH definition : A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in turn associated with dopaminergic receptor blockade (see RECEPTORS, DOPAMINE) in the BASAL GANGLIA and HYPOTHALAMUS, and sympathetic dysregulation. Clinical features include diffuse MUSCLE RIGIDITY; TREMOR; high FEVER; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum CPK level elevation and a leukocytosis may also be present. (From Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49(9):1163-72);

MeSH synonym : nms (neuroleptic malignant syndrome); neuroleptic malignant syndromes; syndrome, neuroleptic malignant; syndromes, neuroleptic malignant; nmss (neuroleptic malignant syndrome);

MeSH hyponym : Neuroleptic-Induced neuroleptic malignant syndrome; Neuroleptic Induced Neuroleptic Malignant Syndrome; Neuroleptic-Malignant Syndrome, Neuroleptic Induced; Neuroleptic Malignant Syndrome, Neuroleptic Induced;

MeSH annotation : caused by tranquilizing agents so do not use /chem ind;

Wikipedia link : https://en.wikipedia.org/wiki/Neuroleptic malignant syndrome;

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A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in turn associated with dopaminergic receptor blockade (see RECEPTORS, DOPAMINE) in the BASAL GANGLIA and HYPOTHALAMUS, and sympathetic dysregulation. Clinical features include diffuse MUSCLE RIGIDITY; TREMOR; high FEVER; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum CPK level elevation and a leukocytosis may also be present. (From Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49(9):1163-72)

https://www.medg.fr/syndrome-malin-des-neuroleptiques
2018
France
teaching material
scientific and technical information
Neuroleptic malignant syndrome
neuroleptic malignant syndrome
neuroleptic malignant syndrome
Neuroleptic-Induced neuroleptic malignant syndrome

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http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=FR&Expert=94093
2017
false
false
false
France
emergency treatment
practice guideline
neuroleptic malignant syndrome

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https://canadiensensante.gc.ca/recall-alert-rappel-avis/hc-sc/2015/43469a-fra.php
2015
false
false
false
Canada
French
English
pharmacovigilance note
donepezil
alzheimer disease
rhabdomyolysis
neuroleptic malignant syndrome
administration, oral
risk
risk factors
drug monitoring
Donepezil

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https://www.hug.ch/sites/interhug/files/structures/pharmacologie_et_toxicologie_cliniques/documents/cappinfo55.pdf
2009
Switzerland
journal article
neuroleptic malignant syndrome
Neuroleptic-Induced neuroleptic malignant syndrome
neuroleptic malignant syndrome
poisoning, nos
poisoning
Poisoning
Neuroleptic malignant syndrome
poisoning

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http://www.cbip.be/Folia/Index.cfm?FoliaWelk=F35F02B
2008
Belgium
French
Dutch
neuroleptic malignant syndrome
antipsychotic agents
serotonin syndrome
serotonin agents
journal article
drug information

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26/04/2025


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